Lab: K. Latham
Oocyte Spindle Quality
I study oocyte spindle biology. Although the meiotic spindle is similar in some ways to the mitotic spindle, it has many meiosis-specific mechanisms controlling spindle formation and meiotic progression. I am most interested in factors affecting spindle structure and function, which can result in aneuploidy if perturbed. My PhD research has involved in vitro maturation of mouse oocytes in a variety of conditions to determine the downstream affect on MI and MII spindle structure.
I began my Girl Scouts outreach program with the hope of inspiring young women in science. Previously a Girl Scout myself, I understood the value of Girl Scouts and thought it would be the perfect medium to teach girls about being in STEM fields. During my activity, we do a DNA isolation, a crime DNA gel, and make a DNA model. I have done this presentation with all ages of girls and each time is a new and fun experience. We talk about doing experiments, what it’s like to be a scientist, and to never feel that you cannot do something because you are a girl! I am continually impressed by these amazing girls!
Severance, A., Latham, K. Meeting the meiotic challenge: Specializations in mammalian oocyte spindle formation. Molecular Reproduction and Development. Molecular Reproduction and Development. March 2018. doi: 10.1002/mrd.22967.
“PLK1 regulates EIF4EBP1 phosphorylation on mouse oocyte spindles”
Frontiers in Reproductive Epigenetics May 2017
“PLK1 regulates EIF4EBP1 at the meiotic spindle”
“4E-BP1 serine 65 phosphorylation at the meiotic spindle is responsive to Plk1”
Michigan Alliance for Reproductive Technologies and Sciences 2017
Oral and poster presentation. Won best oral presentation award.
“PLK1 is the primary regulator of EIF4EBP1 phosphorylation at the meiotic spindle”