Gene Expression & Regulation

Gene Expression & Regulation

The regulated expression of genes is critical for all forms of life to effectively survive and thrive in their environment. Some common regulatory mechanisms are used by plants, animals, fungi, and microbes to control gene expression, but the complexity escalates from prokaryotes to eukaryotes. The study of these phenomena unites one of the largest groups of researchers in the Genetics Program at MSU.

Gene expression may change in response to physical signals from the environment, interactions between species, and signals within an organism. Regulatory mechanisms operate at many levels: through alterations in DNA (chromatin) structure, modification of transcription, stability, or translation of mRNA, or alterations in protein activity through post-translational modification. These mechanisms are studied in laboratories at MSU using state-of-the-art methodologies coupled with classical methods to more fully understand the processes of gene regulation. It is the combination of these strategies that is the strength of this group.

The approaches to study gene expression and regulation vary from the atomic level to the molecular level to the population level, and this depth of examination is reflected in the research groups composing this area of the MSU Genetics Program. Techniques of biochemistry, microbiology, molecular biology, and genomics, are used in the study of such varied areas as genetic and infectious diseases of animals (Ewart, Mansfield, Mulks), humans (Arvidson, Bagdasarian, Mansfield, Triezenberg), and plants (Howe, Sticklen, Trail, Walton); cancer (Esselman, Fluck, Kopachik, McCormick, Schwartz, Zacharewski), development (Arnosti, Kende, Kroos, vanNocker), bioremediation (Reddy, Rugh), and microbial ecology (Schmidt, Thomashow). Nutrition and improvement of crop production is a prominent area studied at all levels by a large number of researchers (Della Penna, Han, Nadler, Ohlrogge, Sticklen,). The research also encompasses basic cellular processes such as transcription (Burton, Geiger, Kuo, Thomashow, Triezenberg), post-transcriptional RNA modification (Koslowsky, Patterson), translation, and organelle division (Osteryoung). Specialized classes and research opportunities are offered through the Gene Expression in Disease and Development focus group, composed of members of the Genetics Program whose research is concentrated on identifying basic mechanisms of transcriptional control (www.bch.msu.edu/GEDD).

Arora, Ripla
Arora, Ripla

(Department of Obstetrics Gynecology and Reproductive Biology)

Institute for Quantitative Health Science and Engineering Ripla@msu.edu

Hsu, Polly
Hsu, Polly

(Department of Biochemistry & Molecular Biology)

Using experimental and computational approaches to study genome-wide mRNA translation and identify novel peptides; plant responses under diurnal cycles and environmental stress; circadian rhythms.

pollyhsu@msu.edu

David Arnosti
David Arnosti

Transcriptional repression and Drosophila development

Cindy Arvidson
Cindy Arvidson

Regulation of virulence and gene expression in the pathogenic Neisseriae; mechanisms of action of probiotic Lactobacilli

Ingo Braasch
Ingo Braasch

(Intergrative Biology), Comparative genomics and gene family evolution in vertebrates, Evo-Devo, developmental genetics in zebrafish and other fish systems. braasch@msu.edu

Robin Buell
Robin Buell

Genomics of plants and plant pathogens

 

 

Christina Chan
Christina Chan

Apply system biology approaches to reconstruct signaling and gene regulatory pathways to help elucidate disease mechanisms and identify pharmaceutical targets

Chen Chen
Chen Chen

Gene expression in germ cells

Henry Chung
Henry Chung

(Entomology)  Investigating the molecular mechanisms underlying environmental adaptation and reproductive isolation. hwchung@msu.edu

Jin Chen
Jin Chen

Developing data mining and graph mining methods for deciphering genomic data, especially algorithms for systems level analysis of gene regulatory programs

Paul Coussens
Paul Coussens

Genetics of immune responses to chronic infections caused by Mycobacteria and some retroviruses

Yuehua Cui
Yuehua Cui

Genetic association studies, gene network inference, gene-gene and gene-environment interactions, Methylation and ChIP-seq data analysis

Dean DellaPenna
Dean DellaPenna

Gene expression for cell wall synthesis and secondary metabolite production

Danny Ducat
Danny Ducat

Heterologous gene expression systems in cyanobacteria, regulation of endogenous genes

Yann Dufour
Yann Dufour

Genetic basis of phenotypic diversity in bacterial social behavior, cell-to-cell signaling, and chemotaxis

Catherine Ernst
Catherine Ernst

Transcriptional regulation and QTL discovery in pigs; genetics of skeletal muscle development and behavior

Susan Ewart
Susan Ewart

Variations in gene expression in inherited diseases of animals

Eva Maria Farre
Eva Maria Farre

Regulation of the Arabidopsis circadian clock transcriptional network

Monique Floer
Monique Floer

Chromatin architecture and gene regulation; proinflammatory genes of mouse macrophages

David R. Foran
David R. Foran

Development and gene expression of forensically useful flies