Genetics of Inherited Disorder of Human and Animal Diseases

Genetics of Inherited Disorder of Human and Animal Diseases

Inherited disorders and genetic diseases that are due to mutations in one or more genes causeeconomic loss and suffering in both humans and animals. Disorders can range from the loss of entire chromosomes to small changes in a single gene. Some disorders are complex because they may result from mutations in multiple genes, as is true for many cancers. In other cases, the inheritance pattern may be complicated because of differential penetrance resulting from environmental influences. The understanding of how variation in one or more genes leads to disease and the resulting implementation of this knowledge are key driving forces of the scientific and industrial communities. Recent advances in molecular genetics and associated technologies have greatly enhanced our ability to identify and characterize disease genes and pathways.

Research groups at MSU use cutting-edge and multidisciplinary approaches, and have access to DNA sequencing, microarray, proteomic, and bioinformatic core facilities. Efforts on human diseases, investigation of animal models of human disease, disease pathology in humans and animals, gene mapping, genetic selection, and the influence of environmental factors are just a few of the research areas that students may pursue. The high amount of formal and informal interactions between groups ensures a rich experience.

Arora, Ripla
Arora, Ripla

(Department of Obstetrics Gynecology and Reproductive Biology)

Institute for Quantitative Health Science and Engineering Ripla@msu.edu

Arthur Alberts
Arthur Alberts

Role of small GTPases in organizing the actin and microtubule cytoskeleton in normal breast tumor cell

 

Ingo Braasch
Ingo Braasch

(Intergrative Biology), Comparative genomics and gene family evolution in vertebrates, Evo-Devo, developmental genetics in zebrafish and other fish systems. braasch@msu.edu

Chen Chen
Chen Chen

Mouse models of human infertility

Hans Cheng
Hans Cheng

Herpes virus-induced T cell cancer of chickens

Susan E. Conrad
Susan E. Conrad

Control of proliferation in normal and transformed cells; estrogen regulation of human breast cancer cell proliferation

Charles Lee Cox
Charles Lee Cox

Neurophysiology and pharmacology of neocortical and thalamic neurons in the mammalian central nervous system

Julia Ganz
Julia Ganz

(Integrative Biology) Development and regeneration of the enteric nervous system (ENS) in zebrafish; Zebrafish CRISPR gene knock-out models for ENS diseases; Signaling pathways in neural crest development. ganz@msu.edu

Brian Gulbransen
Brian Gulbransen

(Physiology) Genomic alterations to specific cells in the nervous system that contribute to neuroinflammation in gastrointestinal disease. gulbrans@msu.edu

Wen Huang
Wen Huang

(Animal Science), Genetics and evolution of complex quantitative traits using a combination of computational and empirical approaches. huangw53@msu.edu

Andras Komaromy
Andras Komaromy

Investigation of molecular and cellular disease mechanisms of inherited retinal and optic nerve disorders. Development of new treatments using gene therapy and neuroprotective agents

Min-Hao Kuo
Min-Hao Kuo

Chromatin modifications during tumorigenesis

Laura McCabe
Laura McCabe

Induction of osteoblast differentiation to treat bone cancer

Quing Lu
Quing Lu

Statistical genetics in human complex diseases

Katheryn Meek
Katheryn Meek

Cell cycle control

Richard J. Miksicek
Richard J. Miksicek

Breast cancer and normal mammary gland biology, emphasizing the role of steroid hormones and their receptors in gene expression and cell growth

Kyle E. Miller
Kyle E. Miller

Analysis of genes involved in axonal elongation during development

Cindy Miranti
Cindy Miranti

Role of integrins and cell adhesion, signal transduction, and growth factor receptors in melanoma and prostate tumorigenesis

Brian C. Schutte
Brian C. Schutte

Genetic and genomic approaches to discover genes involved in common and genetically complex human disorders, such as cleft lip and palate

Richard Schwartz
Richard Schwartz

Oncogenesis and regulation of cell growth in hematopoietic cells