Genetics of the Cell Cycle and Cancer

Genetics of the Cell Cycle and Cancer

Normal cell growth and division depend on precise regulation of the cell cycle. Loss of those controls in animal cells can result in unrestrained cell division. The consequences of this include cell proliferation, tumorigenesis and cancer and all of these are topics under study by a number of research groups at Michigan State University.

The accumulation of mutations contributes to the oncogenic transformation of cells, and hence the occurrence and repair of mutations is an important area of study. Cellular perception of external signals also plays a critical role in the control of cell division. Mutations in either the signals or their receptors can result in a stimulation of cell division. The receptors and kinases responsible for signal recognition and transduction are being studied by several research groups using techniques of molecular genetics. Molecular genetic tools are also applied to the study of tumor viruses, which integrate into the genome and stimulate replication and cell division. Physiological and molecular characterizations of tumor development are being conducted to help establish a better understanding of the processes of cellular transformation using animal cell culture lines, mice, and humans. Other investigations focus on the genetic basis of cancer in chickens and dogs. Within this research area, dynamic interactions and on-going collaborations are centered around studies of breast cancer, gene expression, and mutagenesis and repair.

Arthur Alberts
Arthur Alberts

Role of small GTPases in organizing the actin and microtubule cytoskeleton in normal breast tumor cells

Eran Andrechek
Eran Andrechek

Bioinformatic approaches in combination with model systems to examine breast cancer

Hans Cheng
Hans Cheng

Herpes virus-induced T cell cancer of chickens

Susan E. Conrad
Susan E. Conrad

Control of proliferation in normal and transformed cells; estrogen regulation of human breast cancer cell proliferation

Michele Fluck
Michele Fluck

Tumor viruses: the effect of polyomavirus on viral and host gene expression and replication; mammary gland oncogenesis

Min-Hao Kuo
Min-Hao Kuo

Chromatin modifications during tumorigenesis

Jeff MacKeigan
Jeff MacKeigan

Systems biology integrates multiple disciplines such as biochemistry, mathematics, and genetics to investigate unanswered biological questions

Laura McCabe
Laura McCabe

Induction of osteoblast differentiation to treat bone cancer

Katheryn Meek
Katheryn Meek

Cell cycle control

Richard J. Miksicek
Richard J. Miksicek

Breast cancer and mammary gland biology, emphasizing the role of steroid hormones and their receptors in gene expression and cell growth

Cindy Miranti
Cindy Miranti

Role of integrins and cell adhesion, signal transduction, and growth factor receptors in melanoma and prostate tumorigenesis

John Risinger
John Risinger

Molecular genetic basis for gynecologic cancers

Richard Schwartz
Richard Schwartz

My primary research interests focus on the impact of a high fat diet on mammary tumorigenesis, the role of inflammatory and immune processes in mammary tumorigenesis, and the roles of estrogen and progesterone in regulating the expression of proinflammatory genes in mammary epithelial cells and inflammatory processes in the mammary gland

Jose Teixeira
Jose Teixeira

Use mouse models in vivo and human cells in vitro to study the molecular mechanisms of reproductive tract and gonadal development and the pathological consequences of their dysregulation

Hua Xiao
Hua Xiao

Roles of transcription cofactors in breast and liver cancers; mechanism and regulation of gene expression

Chengfeng Yang
Chengfeng Yang

The roles of microRNAs and long non-coding RNAs in cancer

Kefei Yu
Kefei Yu

Molecular immunology, recombination and class switching in immunoglobulin genes

Villma Yuzbasiyan-Gurkan
Villma Yuzbasiyan-Gurkan

Genetics of cancer in purebred dogs

Tim Zacharewski
Tim Zacharewski

Gene expression profiling of cancer cells